2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as next-generation antisense and antigene agents.
نویسنده
چکیده
Novel 2'-O,4'-C-ethylene nucleosides have been synthesized as building blocks for antisense and antigene oligonucleotides. 2'-O,4'-C-Ethylene-bridged nucleic acids (ENA) comprising 2'-O,4'-C-ethylene nucleosides have considerable affinity to complementary RNA and double-stranded DNA. Incorporation of 2'-O,4'-C-ethylene nucleosides into oligonucleotides dramatically increase their resistance against exonucleases. In this review, the properties of ENA oligonucleotides and some of their applications as antisense and antigene oligonucleotides are described.
منابع مشابه
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ورودعنوان ژورنال:
- Biological & pharmaceutical bulletin
دوره 27 4 شماره
صفحات -
تاریخ انتشار 2004